
| Type | Primary Mechanism | Common Symptoms | Considerations |
|---|---|---|---|
| Inflammatory-Mediated | Chronic inflammation disrupting tight junctions | Abdominal pain, diarrhea, systemic inflammation | Often associated with IBD, celiac disease, or chronic infections |
| Stress-Induced Permeability | Stress hormones affecting gut barrier function | Digestive symptoms during stress, mood-gut connection | Involves gut-brain axis disruption and nervous system dysregulation |
| Toxin-Related Damage | Environmental toxins or medications compromising barrier | Food sensitivities, chemical sensitivities, fatigue | May involve NSAIDs, alcohol, or environmental toxin exposure |
| Microbiome-Driven | Dysbiotic bacteria producing inflammatory compounds | Bloating, irregular bowel movements, brain fog | Often includes SIBO, candida overgrowth, or bacterial imbalances |

Finding the root cause of leaky gut is often apparent through careful evaluation of a patient’s medical history and symptoms. At times comprehensive assessment is necessary. At Whole Gut Health, we use advanced diagnostics to evaluate intestinal barrier integrity and contributing factors.
Testing options may include:
We design testing protocols based on your specific symptoms and health history to identify all factors contributing to barrier dysfunction.

Our Three-Phase Gut Barrier Restoration Protocol Includes:
1. Assessment and Root-Cause Identification
2. Targeted Intervention
3. Rebuilding and Prevention

Dr. Alexandra Shustina, NYC’s and Miami’s premier gut health specialist doctor is a board-certified gastroenterologist and internist. She is a gut health specialist with training in conventional gastroenterology and functional gut health. She is an expert in the gut microbiome and its role in health and wellness.
At Whole Gut Health, our care is led by an experienced functional medicine team with a deep understanding of the gut microbiome and advanced diagnostics. We combine evidence-based strategies from conventional gastroenterology with a functional and integrative lens to give you the clarity and support needed for long-term healing.
Increased intestinal permeability occurs when the tight junctions between intestinal cells become compromised, allowing larger molecules, bacteria, and toxins to pass through the intestinal wall into the bloodstream. This can trigger immune responses and systemic inflammation affecting health throughout the body.
Inflammatory-Mediated
Stress-Induced Permeability
Toxin-Related Damage
Microbiome-Driven
Comprehensive assessment requires multiple testing approaches. Testing options include:
Comprehensive Stool Analysis
SIBO Breath Testing
Food Sensitivity Testing
Zonulin and Permeability Markers
Functional Lab Work
Testing protocols are designed based on your specific symptoms and health history.
Your comprehensive three-phase gut barrier restoration protocol includes:
1. Assessment and Root-Cause Identification
2. Targeted Intervention
3. Rebuilding and Prevention
Why is it important to identify the underlying causes of intestinal permeability?
Different causes require different treatment approaches. For example:
Different causes require different treatment approaches. For example:
Symptoms can return if underlying causes aren't fully addressed or if new triggers are encountered. This is why our protocol includes a comprehensive rebuilding and prevention phase that focuses on:
Symptoms can return if underlying causes aren't fully addressed or if new triggers are encountered. This is why our protocol includes a comprehensive rebuilding and prevention phase that focuses on:
At Whole Gut Health, we take a comprehensive, root-cause approach to gut barrier restoration. We combine evidence-based strategies from conventional gastroenterology with functional medicine principles, focusing on:
Dr. Alexandra Shustina is a board-certified gastroenterologist and internist who serves as NYC's and Miami's premier gut health specialist. She has completed training in both conventional gastroenterology and functional gut health, with expertise in the gut microbiome and intestinal barrier function.
The first step is scheduling a comprehensive consultation where we'll:
Contact our office to schedule your initial consultation and begin your journey toward optimal gut barrier function and overall wellness.
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