Increased Intestinal Permeability (Leaky Gut)

Chronic digestive symptoms, unexplained food sensitivities, and persistent inflammation throughout your body aren't random occurrences—they may signal that your intestinal barrier isn't functioning properly. Research shows that increased intestinal permeability plays a role in numerous gastrointestinal conditions including celiac disease, Crohn's disease, and IBS, which is why our team focuses on comprehensive gut barrier assessment and restoration as a foundation for lasting digestive wellness.
A man with a beard, focusing on enhancing his sleep and gut health, is resting on a couch in a blue shirt with his head on a yellow pillow and eyes gently closed.

What Exactly Is Increased Intestinal Permeability?

Increased intestinal permeability, commonly referred to as "leaky gut," occurs when the tight junctions between intestinal cells become compromised, allowing larger molecules, bacteria, and toxins to pass through the intestinal wall into the bloodstream. In a healthy gut, this barrier is selectively permeable—allowing beneficial nutrients through while blocking harmful substances. When this barrier becomes compromised, it can trigger immune responses and systemic inflammation that extend far beyond the digestive system.

Types of Barrier Dysfunction and Their Characteristics

Intestinal permeability can manifest in different ways depending on the underlying cause and affected areas. Each type requires specific assessment and targeted intervention strategies.
Type Primary Mechanism Common Symptoms Considerations
Inflammatory-Mediated Chronic inflammation disrupting tight junctions Abdominal pain, diarrhea, systemic inflammation Often associated with IBD, celiac disease, or chronic infections
Stress-Induced Permeability Stress hormones affecting gut barrier function Digestive symptoms during stress, mood-gut connection Involves gut-brain axis disruption and nervous system dysregulation
Toxin-Related Damage Environmental toxins or medications compromising barrier Food sensitivities, chemical sensitivities, fatigue May involve NSAIDs, alcohol, or environmental toxin exposure
Microbiome-Driven Dysbiotic bacteria producing inflammatory compounds Bloating, irregular bowel movements, brain fog Often includes SIBO, candida overgrowth, or bacterial imbalances

Why Increased Intestinal Permeability Impacts More Than Digestion

When the intestinal barrier becomes compromised, the effects extend throughout the entire body due to the gut's central role in immune function and nutrient absorption. A compromised gut barrier can allow inflammatory molecules to enter the bloodstream, triggering immune responses that may contribute to autoimmune conditions, mood disorders, and systemic inflammation. This can disrupt hormone production, neurotransmitter synthesis, and nutrient absorption—affecting energy levels, cognitive function, skin health, and overall vitality.
In an office adorned with sheer curtains and a vibrant tree painting, two people sit across from each other, engaging in a thoughtful discussion about the advantages of prioritizing gut health.

Common Signs of Increased Intestinal Permeability Include:

  • Chronic digestive issues (bloating, gas, irregular bowel movements)
  • Multiple food sensitivities or intolerances
  • Frequent infections or poor immune function
  • Skin problems (eczema, acne, rashes)
  • Fatigue, brain fog, or cognitive difficulties
  • Joint pain or muscle aches
  • Mood changes, anxiety, or depression
  • Seasonal allergies or environmental sensitivities
  • Autoimmune condition diagnosis
  • Nutrient deficiencies despite adequate dietary intake

Diagnostic Options at Whole Gut Health

Finding the root cause of leaky gut is often apparent through careful evaluation of a patient’s medical history and symptoms. At times comprehensive assessment is necessary.  At Whole Gut Health, we use advanced diagnostics to evaluate intestinal barrier integrity and contributing factors.

Testing options may include:

  • Comprehensive Stool Analysis to assess microbiome balance, inflammation markers, and digestive function.
  • SIBO Breath Testing to identify bacterial overgrowth that may compromise gut barrier function.
  • Applied Kinesiology also known as muscle testing to determine root causes and triggers.  Applied Kinesiology allows a for a much broader ability to diagnose than laboratory tests. 
  • Osteopathic Visceral Evaluation to assess physical restrictions, symmetry, and subtle motions of the internal organs.   This provides information on the function of the organs as well as their associated meridians.
  • Organic Acids Testing to evaluate for fungal overgrowth and metabolic dysfunction.
  • Functional Lab Work including nutrient assessments, inflammatory markers, and immune system evaluation.  There are several popular tests which from our experience do not provide value in diagnosis.  We always use strategic and only necessary testing.

We design testing protocols based on your specific symptoms and health history to identify all factors contributing to barrier dysfunction.

Why Whole Gut Health
Is Different

At Whole Gut Health, we go beyond conventional symptom management and traditional functional medicine protocols. We trust your body's innate ability to heal itself when given the right support. In Dr. Shustina's many years of practice, she has seen that many digestive diseases have their root cause in emotional traumas and unhealed wounds. When these underlying causes are healed, the body can heal from the inside out in a lasting way. We focus on the mind-gut connection, incorporating energy healing techniques, personalized nutrition that evolves as you heal, and integrative approaches addressing mind, body, and spirit. If this resonates with you, contact our office to schedule your consultation and take the first step on your healing journey.

Our Intestinal Permeability Treatment Approach

Our Three-Phase Gut Barrier Restoration Protocol Includes:

1. Assessment and Root-Cause Identification

  • Comprehensive evaluation of barrier function
  • Detailed analysis of diet, stress, and environmental factors
  • Identification of contributing factors including:
    • Bacterial or fungal overgrowth
    • Food sensitivities and inflammatory triggers
    • Medication effects and toxin exposure
    • Stress and gut-brain axis dysfunction
    • Nutrient deficiencies affecting barrier integrity

2. Targeted Intervention

  • Treatment of underlying infections or bacterial imbalances
  • Elimination of inflammatory foods and environmental triggers
  • Targeted supplementation with gut barrier-supporting nutrients
  • Stress management and nervous system support
  • Energy healing to heal the mind body component
  • Visceral manipulation and other osteopathic techniques
  • Anti-inflammatory protocols and immune system modulation

3. Rebuilding and Prevention

  • Comprehensive gut lining repair with specific nutrients and compounds
  • Microbiome restoration and diversity optimization
  • Long-term dietary strategies supporting barrier function
  • Stress resilience building and lifestyle optimization
  • Ongoing support to maintain intestinal barrier integrity
A person with long, light brown hair sits at a table, enjoying a gut-friendly meal, wearing a navy blouse against the backdrop of a calming blue curtain.

Expert-Led, Patient-Centered Care

Dr. Alexandra Shustina, NYC’s and Miami’s premier gut health specialist doctor is a board-certified gastroenterologist and internist. She is a gut health specialist with training in conventional gastroenterology and functional gut health. She is an expert in the gut microbiome and its role in health and wellness.

At Whole Gut Health, our care is led by an experienced functional medicine team with a deep understanding of the gut microbiome and advanced diagnostics. We combine evidence-based strategies from conventional gastroenterology with a functional and integrative lens to give you the clarity and support needed for long-term healing.

Frequently Asked Questions

Increased intestinal permeability occurs when the tight junctions between intestinal cells become compromised, allowing larger molecules, bacteria, and toxins to pass through the intestinal wall into the bloodstream. This can trigger immune responses and systemic inflammation affecting health throughout the body.

Inflammatory-Mediated

  • Primary mechanism: Chronic inflammation disrupting tight junctions
  • Common symptoms: Abdominal pain, diarrhea, systemic inflammation
  • Often associated with IBD, celiac disease, or chronic infections

Stress-Induced Permeability

  • Primary mechanism: Stress hormones affecting gut barrier function
  • Common symptoms: Digestive symptoms during stress, mood-gut connection
  • Involves gut-brain axis disruption and nervous system dysregulation

Toxin-Related Damage

  • Primary mechanism: Environmental toxins or medications compromising barrier
  • Common symptoms: Food sensitivities, chemical sensitivities, fatigue
  • May involve NSAIDs, alcohol, or environmental toxin exposure

Microbiome-Driven

  • Primary mechanism: Dysbiotic bacterial populations producing inflammatory compounds
  • Common symptoms: Bloating, irregular bowel movements, brain fog
  • Often includes SIBO, candida overgrowth, or bacterial imbalances

  • Chronic digestive issues (bloating, gas, irregular bowel movements)
  • Multiple food sensitivities or intolerances
  • Frequent infections or poor immune function
  • Skin problems (eczema, acne, rashes)
  • Fatigue, brain fog, or cognitive difficulties
  • Joint pain or muscle aches
  • Mood changes, anxiety, or depression
  • Seasonal allergies or environmental sensitivities
  • Autoimmune condition diagnosis
  • Nutrient deficiencies despite adequate dietary intake

Comprehensive assessment requires multiple testing approaches. Testing options include:

Comprehensive Stool Analysis

  • Assesses microbiome balance and inflammation markers
  • Evaluates digestive function

SIBO Breath Testing

  • Identifies bacterial overgrowth that may compromise gut barrier function

Food Sensitivity Testing

  • Determines immune reactions contributing to intestinal inflammation

Zonulin and Permeability Markers

  • Directly assess intestinal barrier function

Functional Lab Work

  • Includes nutrient assessments, inflammatory markers, and immune system evaluation

Testing protocols are designed based on your specific symptoms and health history.

Your comprehensive three-phase gut barrier restoration protocol includes:

1. Assessment and Root-Cause Identification

  • Comprehensive evaluation of barrier function
  • Detailed analysis of diet, stress, and environmental factors
  • Identification of contributing factors including infections, food sensitivities, toxin exposure, and nutrient deficiencies

2. Targeted Intervention

  • Treatment of underlying infections or bacterial imbalances
  • Elimination of inflammatory foods and environmental triggers
  • Targeted supplementation with gut barrier-supporting nutrients
  • Stress management and nervous system support
  • Energy healing to heal the mind body component
  • Visceral manipulation and other osteopathic techniques
  • Anti-inflammatory protocols and immune system modulation

3. Rebuilding and Prevention

  • Comprehensive gut lining repair with specific nutrients and compounds
  • Microbiome restoration and diversity optimization
  • Long-term dietary strategies supporting barrier function
  • Stress resilience building and lifestyle optimization
  • Ongoing support to maintain intestinal barrier integrity

Why is it important to identify the underlying causes of intestinal permeability?

Different causes require different treatment approaches. For example:

  • Inflammatory-mediated permeability may need anti-inflammatory protocols
  • Stress-induced permeability requires gut-brain axis support
  • Toxin-related damage needs detoxification and barrier repair
  • Microbiome-driven issues require specific antimicrobial treatments and rebalancing

Different causes require different treatment approaches. For example:

  • Inflammatory-mediated permeability may need anti-inflammatory protocols
  • Stress-induced permeability requires gut-brain axis support
  • Toxin-related damage needs detoxification and barrier repair
  • Microbiome-driven issues require specific antimicrobial treatments and rebalancing

Can intestinal permeability symptoms recur after treatment?

Symptoms can return if underlying causes aren't fully addressed or if new triggers are encountered. This is why our protocol includes a comprehensive rebuilding and prevention phase that focuses on:

  • Long-term gut barrier maintenance strategies
  • Stress management and resilience building
  • Environmental toxin awareness and avoidance
  • Ongoing microbiome support
  • Sustainable dietary and lifestyle practices

Symptoms can return if underlying causes aren't fully addressed or if new triggers are encountered. This is why our protocol includes a comprehensive rebuilding and prevention phase that focuses on:

  • Long-term gut barrier maintenance strategies
  • Stress management and resilience building
  • Environmental toxin awareness and avoidance
  • Ongoing microbiome support
  • Sustainable dietary and lifestyle practices

At Whole Gut Health, we take a comprehensive, root-cause approach to gut barrier restoration. We combine evidence-based strategies from conventional gastroenterology with functional medicine principles, focusing on:

  • Advanced testing to identify all contributing factors
  • Personalized treatment protocols based on individual causes
  • Comprehensive gut barrier repair and microbiome restoration
  • Long-term wellness strategies rather than symptom suppression

Dr. Alexandra Shustina is a board-certified gastroenterologist and internist who serves as NYC's and Miami's premier gut health specialist. She has completed training in both conventional gastroenterology and functional gut health, with expertise in the gut microbiome and intestinal barrier function.

The first step is scheduling a comprehensive consultation where we'll:

  • Review your symptoms and health history in detail
  • Determine the most appropriate testing strategy for your case
  • Develop a personalized gut barrier restoration plan based on your specific needs and underlying causes

Contact our office to schedule your initial consultation and begin your journey toward optimal gut barrier function and overall wellness.

Locations

New York

PHONE

(212) 634 4233

ADDRESS

635 Madison Ave.
New York, NY 10022

BUSINESS HOURS

Monday - Friday
9:00am - 5:00pm
Saturday - Sunday - Closed

BUSINESS HOURS

Monday - Friday
9:00am - 5:00pm
Saturday - Sunday - Closed

Miami

PHONE

(212) 634 4233

ADDRESS

407 Lincoln Rd Suite 10B
Miami Beach, FL 33139

BUSINESS HOURS

Monday - Friday
9:00am - 5:00pm
Saturday - Sunday - Closed

BUSINESS HOURS

Monday - Friday
9:00am - 5:00pm
Saturday - Sunday - Closed

Our Testimonials

google
david glickman
david glickman
October 27, 2024
google
Dina Kushnir
Dina Kushnir
October 15, 2024
google
Leah Glickman
Leah Glickman
September 19, 2024
google
Ruthi Woonteiler
Ruthi Woonteiler
July 11, 2024
google
Rochel Gordon
Rochel Gordon
July 4, 2024
google
Michael Dym
Michael Dym
July 4, 2024
google
Harry Willner
Harry Willner
June 26, 2024
google
jessica mcmillan
jessica mcmillan
June 20, 2024
google
m s
m s
March 27, 2024
google
Dalit Lonstein
Dalit Lonstein
January 30, 2024
google
Rachel S
Rachel S
October 11, 2023
google
Sibel Sebi Sharabi
Sibel Sebi Sharabi
August 30, 2023
google
Gabriela Salazar
Gabriela Salazar
July 4, 2023
google
Clay Simonsen
Clay Simonsen
June 5, 2023
Daniela Chaparro
Daniela Chaparro
June 4, 2023

Stay Informed and Stay Healthy!

Receive expert tips, exclusive content, and the latest updates on gut health straight to your inbox. Don’t miss out on valuable insights for better nutrition and overall well-being. Subscribe now and take the first step towards a healthier you!

Start Your Journey to Better Health

Let us help. CALL NOW

Whole Gut Health - Functional Medicine and Integrative Gastroenterology Practice. © Copyright 2024
This website is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and never disregard professional medical advice or delay in seeking it because of something you have read on this website. No physician-patient relationship is created by this web site or its use. Neither Whole Gut Health nor any contributor to this web site, makes any representations, expressed or implied, with respect to the information provided herein or to its use.